Tamura Akiko, Kogure Akiko, Watanabe Goro, Kishi Shoji, Hori Sadao
Department of Opthalmology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
Nippon Ganka Gakkai Zasshi. 2013 Feb;117(2):110-6.
To investigate the relationship between age and chorioretinal hemodynamics in normal volunteers examined with Laser speckle flowgraphy (LSFG-NAVI).
107 eyes of 107 healthy volunteers aged from 21 to 78 years old were included. Laser speckle flowgraphy measurements of relative blood velocity (mean blur rate: MBR), skewness in the wave of blood velocity (Skew) and blowout score (BOS), which indicates ease of blood flow, were obtained as parameters of chorioretinal hemodynamics. MBR and BOS were measured on the optic disc and macula, and BOS and Skew were measured in retinal arteries and veins.
There was a negative correlation between age and MBR on the optic disc and macula. There was a negative correlation between age and BOS on the optic disc, macula, retinal arteries and retinal veins.
There was a negative correlation between MBR, BOS and age in all measurement areas. MBR and BOS may serve as indexes for a new interpretation of fundus pathology including age-related arterial sclerosis.
利用激光散斑血流图（LSFG-NAVI）研究正常志愿者年龄与脉络膜视网膜血流动力学之间的关系。
纳入107名年龄在21至78岁之间的健康志愿者的107只眼睛。获取相对血流速度（平均模糊率：MBR）、血流速度波形的偏度（Skew）以及表示血流难易程度的吹脱分数（BOS）的激光散斑血流图测量值，作为脉络膜视网膜血流动力学参数。在视盘和黄斑处测量MBR和BOS，在视网膜动脉和静脉中测量BOS和Skew。
视盘和黄斑处的年龄与MBR之间存在负相关。视盘、黄斑、视网膜动脉和视网膜静脉处的年龄与BOS之间存在负相关。
在所有测量区域，MBR、BOS与年龄之间均存在负相关。MBR和BOS可作为包括年龄相关性动脉硬化在内的眼底病变新解释的指标。
