鞘氨醇-1-磷酸：分布、代谢及其在细胞功能调节中的作用

Sphingosine-1-phosphate: distribution, metabolism and role in the regulation of cellular functions.

作者信息

Morozov V I, Sakuta G A, Kalinski M I

机构信息

Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, St. Petersburg, Russia.

出版信息

Ukr Biokhim Zh (1999). 2013 Jan-Feb;85(1):5-21. doi: 10.15407/ubj85.01.005.

DOI:10.15407/ubj85.01.005

PMID:23534286

Abstract

The role of sphingosine-1-phosphate (S1P) in regulation of cellular functions and cell protection is reviewed. S1P, along with other sphingolipid metabolites, is believed to act as an intracellular second messenger and as an extracellular mediator molecule. S1P chemistry, production and metabolism are described. Cellular receptors for S1P and their tissue specificity are described. Platelets and erythrocytes have a crucial significance in blood transport of S1P. Hypoxic conditions induce an increase in S1P, which initiates a set of cytoprotective events via its cellular receptors. S1P involvement in regulation of cell migration, myogenesis, control of skeletal muscle function is described. It is shown that S1P balance disturbances may mediate pathological state. S1P system implication in regulation of the most important cellular functions allows considering it as a prospective remedial target.

摘要

综述了1-磷酸鞘氨醇（S1P）在细胞功能调节和细胞保护中的作用。S1P与其他鞘脂代谢产物一起，被认为可作为细胞内第二信使和细胞外介质分子。描述了S1P的化学性质、产生和代谢。描述了S1P的细胞受体及其组织特异性。血小板和红细胞在S1P的血液运输中具有至关重要的意义。低氧条件会导致S1P增加，S1P通过其细胞受体引发一系列细胞保护事件。描述了S1P参与细胞迁移调节、肌生成、骨骼肌功能控制。结果表明，S1P平衡紊乱可能介导病理状态。S1P系统参与调节最重要的细胞功能，使其有望成为一个治疗靶点。