Fonseca Ana Glória
Serviço de Medicina, Hospital Garcia de Orta. Almada. & Departamento de Saúde Publica, Faculdade de Ciências Médicas, Lisboa, Portugal.
Acta Med Port. 2012 Nov-Dec;25(6):433-41. Epub 2013 Jan 28.
Thromboembolic disease and obstetric complications related to ischemia of the placenta are currently the major causes of maternal mortality and morbidity. Thrombophilia been implicated in their aetiology and the magnitude of the risk depends on the type of thrombophilia. As the evidence is still unclear and controversial, questions about the clinical management of pregnant women with thrombophilia are a daily issue. We aim to review, bearing in mind the consensus and controversies, the impact of inherited thrombophilia in the risk of thrombosis related to pregnancy and of obstetric complications. Moreover, the diagnostic, preventive and therapeutic approach during pregnancy and puerperium, including the role of antithrombotic pharmacopoeia available, will be discussed.
血栓栓塞性疾病以及与胎盘缺血相关的产科并发症是目前孕产妇死亡和发病的主要原因。血栓形成倾向被认为与它们的病因有关，风险程度取决于血栓形成倾向的类型。由于证据仍不明确且存在争议，患有血栓形成倾向的孕妇的临床管理问题是日常面临的问题。我们旨在结合共识和争议，回顾遗传性血栓形成倾向对与妊娠相关的血栓形成风险以及产科并发症的影响。此外，还将讨论妊娠和产褥期的诊断、预防和治疗方法，包括现有抗血栓药物的作用。
