Bag Arundhati, Upadhyay Saloni, Jeena Lalit M, Pundir Princi, Jyala Narayan S
Institute of Allied Health (Paramedical) Services, Education and Training, Govt. Medical College, Uttarakhand, India.
Asian Pac J Cancer Prev. 2013;14(1):87-9. doi: 10.7314/apjcp.2013.14.1.87.
Glutathione S-transferases (GSTs) constitute a multigene family of multifunctional phase II metabolic enzymes. GSTT1, an important member of this group has a wide range of substrates including carcinogens. Total homozygous deletion or null genotype resulting in total lack of enzyme activity exists in populations for this enzyme. Since the null genotype may contribute to lower detoxification of carcinogens, this genotype is expected to increase cancer risk. The frequency of the GSTT1 null genotype is known to vary significantly among populations. However, little is known about its distribution in the hilly Kumaun region of northern India. Therefore, in this study, we determined the prevalence of the GSTT1 null polymorphism in the Kumaun popilation by conducting duplex PCR in 365 voluntary healthy individuals. The GSTT1 null genotype was detected in 18.4% of the individuals. Since GSTs play significant role in xenobiotic metabolism, the present data on GSTT1 genotype distribution should contribute in understanding genetic association with cancer risk in this understudied population.
谷胱甘肽S-转移酶（GSTs）构成了一个多功能II相代谢酶的多基因家族。GSTT1是该家族的一个重要成员，其底物范围广泛，包括致癌物。在人群中存在该酶的纯合子完全缺失或无效基因型，导致酶活性完全缺乏。由于无效基因型可能导致致癌物解毒能力降低，因此预计该基因型会增加癌症风险。已知GSTT1无效基因型的频率在不同人群中差异显著。然而，对于其在印度北部库马盎山区的分布情况知之甚少。因此，在本研究中，我们通过对365名自愿参与的健康个体进行双重PCR，确定了库马盎人群中GSTT1无效多态性的患病率。在18.4%的个体中检测到了GSTT1无效基因型。由于GSTs在异源物质代谢中发挥着重要作用，目前关于GSTT1基因型分布的数据应有助于理解这个研究较少的人群中与癌症风险的遗传关联。
