Gadalov V P, Saltanov A I, Parshkov E M, Simakova G M, Liasko L I, Medvedev V N, Efimov K M
Vestn Akad Med Nauk SSSR. 1990(3):22-6.
A modification of neuroleptanalgesia (NLA) has been developed to be applied in operations on the lungs. It is based on the inclusion of indomethacin and diazepam into premedication, on the bolus administration of phentanyl, droperidol, and diazepam prior to the most traumatic stages of the operation, and on the subsequent infusion of phentanyl and droperidol. The modified technique of NLA has been applied in operations on 19 patients with lung cancer. The control (traditional NLA technique) consisted of 20 lung cancer patients. Evaluation of the endocrine response and venous blood plasma concentration of metabolites of polyunsaturated fatty acids showed a possibility for reducing the stress response to the operative trauma by using the modified NLA technique. The advantages of this method are well demonstrated in the course of the postoperative period as a lowered incidence of postoperative inflammatory complications.
一种改良的神经安定镇痛术（NLA）已被研发出来用于肺部手术。它基于在术前用药中加入吲哚美辛和地西泮，在手术最具创伤性阶段之前推注芬太尼、氟哌利多和地西泮，以及随后输注芬太尼和氟哌利多。改良的NLA技术已应用于19例肺癌患者的手术。对照组（传统NLA技术）由20例肺癌患者组成。对内分泌反应和多不饱和脂肪酸代谢产物的静脉血浆浓度的评估表明，使用改良的NLA技术有可能降低对手术创伤的应激反应。在术后期间，该方法的优势得到了充分体现，即术后炎症并发症的发生率降低。
