催产素和1-去氨基-1-碳杂-2-酪氨酸（O-甲基）-催产素对非妊娠和足月妊娠妇女子宫肌层组织的收缩作用。

Contractile effect of oxytocin and 1-deamino-1-carba-2-tyrosine (0-methyl)-oxytocin in myometrial tissue from non-pregnant and term pregnant women.

作者信息

Norström A, Andersson A, Vilhardt H

机构信息

Department of Obstetrics and Gynecology, University of Göteborg, Sahlgren's Hospital, Sweden.

出版信息

Acta Endocrinol (Copenh). 1990 May;122(5):566-8. doi: 10.1530/acta.0.1220566.

DOI:10.1530/acta.0.1220566

PMID:2353554

Abstract

The contractile effect of the analogue 1-deamino-1-carba-2-tyrosine (0-methyl)-oxytocin (carbetocin) on isolated strips from the human myometrium was compared with that of oxytocin. Neither oxytocin nor carbetocin affected contractile activity in strips from non-pregnant women, but both peptides stimulated contractile activity in strips from women at term pregnancy (2 x 10(-11) mol/l, and 10(-10) mol/l, respectively). Thus, carbetocin is almost as potent as oxytocin with regard to stimulating myometrial contractions at term.

摘要

将类似物1-脱氨基-1-碳-2-酪氨酸（0-甲基）-催产素（卡贝缩宫素）对人子宫肌层离体条带的收缩作用与催产素进行了比较。催产素和卡贝缩宫素对非孕妇子宫肌层条带的收缩活性均无影响，但这两种肽均能刺激足月妊娠妇女子宫肌层条带的收缩活性（分别为2×10⁻¹¹mol/L和10⁻¹⁰mol/L）。因此，在足月时刺激子宫肌层收缩方面，卡贝缩宫素的效力几乎与催产素相当。