Fukagai T, Tazawa K, Higaki Y, Imamura K
Department of Urology, School of Medicine, Showa University.
Hinyokika Kiyo. 1990 Mar;36(3):307-17.
To determine the effect on immunoparameters of cryosurgery in cases of stage B prostatic cancer and to determine whether such changes were specifically related to the cryosurgery technique, immunoparameters were measured and compared with cases of prostatic hyperplasia treated by transurethral resection (TUR-P). A decrease in immunoparameters was recognized in the cryosurgery group at 1-3 days postoperatively (increase in IAP, decrease in NK cell activity, decrease in lymphocyte blastogenesis reaction to PHA). The protein histograms, immunoglobulin and IAP changed similarly after the two above procedures. These changes were thought to be due to the invasive nature of the procedures. However, some difference was seen between the cryosurgery group and the TUR-P group in terms of rate of lymphocyte blastogenesis reaction to PHA and Con A, IgG, complement and NK cell activity which might indicate a specific effect of cryosurgery different from TUR-P.
为确定冷冻手术对B期前列腺癌患者免疫参数的影响，并确定这些变化是否与冷冻手术技术有特定关联，对免疫参数进行了测量，并与经尿道前列腺切除术（TUR-P）治疗的前列腺增生患者进行了比较。冷冻手术组术后1-3天免疫参数出现下降（免疫抑制酸性蛋白增加、自然杀伤细胞活性降低、淋巴细胞对PHA的增殖反应降低）。上述两种手术后蛋白质直方图、免疫球蛋白和免疫抑制酸性蛋白的变化相似。这些变化被认为是由于手术的侵入性所致。然而，冷冻手术组与TUR-P组在淋巴细胞对PHA和刀豆蛋白A的增殖反应率、IgG、补体及自然杀伤细胞活性方面存在一些差异，这可能表明冷冻手术有别于TUR-P的特定效应。
