Glynn M F, Cornhill F
Can J Surg. 1975 Jan;18(1):73-6.
The relationship between decreased oxygen affinity of hemoglobin and intraerythrocyte 2,3-diphosphoglycerate (2,3 DPG) concentration was confirmed and its existence during the period of open-heart surgery was demonstrated. It is suggested that the trauma sustained by the erythrocytes during their extracorporeal circulation is responsible, in large measure, for the decrease in 2,3 DPG concentration.
血红蛋白氧亲和力降低与红细胞内2,3 - 二磷酸甘油酸（2,3 - DPG）浓度之间的关系得到了证实，并证明了其在心脏直视手术期间的存在。有人提出，红细胞在体外循环期间遭受的损伤在很大程度上是导致2,3 - DPG浓度降低的原因。
