Faculty of Chemistry and Biochemistry, Inorganic Chemistry I, Ruhr-Universität Bochum, Universitätsstrasse 150, 44801 Bochum, Germany.
Chemistry. 2013 May 17;19(21):6785-90. doi: 10.1002/chem.201201743. Epub 2013 Mar 27.
Crystals of MIL-88B-Fe and NH2-MIL-88B-Fe were prepared by a new rapid microwave-assisted solvothermal method. High-purity, spindle-shaped crystals of MIL-88B-Fe with a length of about 2 μm and a diameter of 1 μm and needle-shaped crystals of NH2-MIL-88B-Fe with a length of about 1.5 μm and a diameter of 300 nm were produced with uniform size and excellent crystallinity. The possibility to reduce the as-prepared frameworks and the chemical capture of carbon monoxide in these materials was studied by in situ ultrahigh vacuum Fourier-transform infrared (UHV-FTIR) spectroscopy and Mössbauer spectroscopy. CO binding occurs to unsaturated coordination sites (CUS). The release of CO from the as-prepared materials was studied by a myoglobin assay in physiological buffer. The release of CO from crystals of MIL-88B-Fe with t(1/2) = 38 min and from crystals of NH2-MIL-88B-Fe with t(1/2) = 76 min were found to be controlled by the degradation of the MIL materials under physiological conditions. These MIL-88B-Fe and NH2-MIL-88B-Fe materials show good biocompatibility and have the potential to be used in pharmacological and therapeutic applications as carriers and delivery vehicles for the gasotransmitter carbon monoxide.
采用一种新的快速微波辅助溶剂热法合成了 MIL-88B-Fe 和 NH2-MIL-88B-Fe 晶体。成功制备出了具有约 2μm 长和 1μm 直径的高纯、纺锤形 MIL-88B-Fe 晶体和具有约 1.5μm 长和 300nm 直径的针形 NH2-MIL-88B-Fe 晶体，这些晶体具有均匀的尺寸和优异的结晶度。通过原位超真空傅里叶变换红外（UHV-FTIR）光谱和穆斯堡尔光谱研究了这些材料中制备的框架的还原和一氧化碳的化学捕获的可能性。CO 结合到不饱和配位位（CUS）。通过在生理缓冲液中的肌红蛋白测定法研究了从制备材料中释放 CO。发现 MIL-88B-Fe 晶体的 CO 释放半衰期 t(1/2) = 38min，NH2-MIL-88B-Fe 晶体的 CO 释放半衰期 t(1/2) = 76min，这是由 MIL 材料在生理条件下的降解控制的。这些 MIL-88B-Fe 和 NH2-MIL-88B-Fe 材料具有良好的生物相容性，有可能作为气体递质一氧化碳的载体和输送工具，用于药理学和治疗应用。
