Department of Neurology, Referral Center for Demyelinating Diseases of the Central Nervous System, University Hospital Center Zagreb, Zagreb, Croatia.
Clin EEG Neurosci. 2013 Oct;44(4):286-90. doi: 10.1177/1550059412467447. Epub 2013 Mar 26.
The aim of this study was to determine the efficacy of tongue somatosensory-evoked potentials (tSSEPs) in evaluation of afferent trigeminal pathway in patients with early multiple sclerosis (MS). The tSSEP was performed on 10 healthy volunteers and 10 patients with the first symptom of MS. Data were compared between the groups, and tSSEP findings of patients with MS were correlated with clinical and magnetic resonance imaging (MRI) data. Among 10 patients, 2 (20%) had clinically evident involvement of the brainstem, 5 (50%) had brainstem lesions on brain MRI, while 9 (90%) had prolonged latencies on tSSEP. Of the 8 patients with no clinical evidence of brainstem pathology, 7 (88%) had prolonged latencies/conduction block on tSSEP. Patients had statistically significant prolongation of N1, P1, and N2 latencies for stimulation of the right side and N2 latency for stimulation of the left side compared to healthy controls. The tSSEP is an efficient method for evaluating the afferent trigeminal pathway in patients with early MS. This study provides evidence that lesions of the afferent trigeminal pathway are more frequently found by tSSEP than by clinical examination or MRI.
本研究旨在确定舌体感诱发电位（tSSEP）在评估早期多发性硬化症（MS）患者传入三叉神经通路中的疗效。对 10 名健康志愿者和 10 名出现 MS 首发症状的患者进行了 tSSEP。比较了两组之间的数据，并将 MS 患者的 tSSEP 结果与临床和磁共振成像（MRI）数据相关联。在 10 名患者中，2 名（20%）有明显的脑干受累，5 名（50%）有脑干 MRI 病变，而 9 名（90%）有 tSSEP 潜伏期延长。在 8 名无明显脑干病变的临床证据的患者中，7 名（88%）有 tSSEP 潜伏期延长/传导阻滞。与健康对照组相比，右侧刺激时 N1、P1 和 N2 潜伏期以及左侧刺激时 N2 潜伏期有统计学意义的延长。tSSEP 是评估早期 MS 患者传入三叉神经通路的有效方法。本研究提供的证据表明，tSSEP 比临床检查或 MRI 更常发现传入三叉神经通路的病变。
