Aravindakshan V, Gettes L S
Cardiovasc Res. 1975 Jan;9(1):19-28. doi: 10.1093/cvr/9.1.19.
We studied the effects of bretylium tosylate and lidocaine on ventricular fibrillation in the isolated, perfused rabbit heart induced by perfusion with potassium-deficient solutions and by premature stimuli. The purpose of the study was to determine if the reported antifibrillatory effects of the drugs could be reproduced in the absence of an intact sympathetic nervous system. Lidocaine in the concentration of 5 mug/ml. prevented ventricular fibrillation induced by both methods while bretylium, in concentrations of 25 to 50 mug/ml. prevented neither type of filbrillation. These results indicate that the antifibrillatory effects of lidocaine can be attributed to drug-induced alterations in cellular electrophysiology, whereas those of bretylium are independent of such changes. Our study suggests that the reported antifibrillatory capability of bretylium is related to the drug's effects at sympathetic nerve terminals and thus is dependent upon an intact sympathetic nervous system.
我们研究了溴苄铵和利多卡因对用低钾溶液灌注及过早刺激诱发的离体灌注兔心脏室颤的影响。本研究的目的是确定在没有完整交感神经系统的情况下，所报道的这些药物的抗纤颤作用是否能够重现。浓度为5微克/毫升的利多卡因可预防两种方法诱发的室颤，而浓度为25至50微克/毫升的溴苄铵对两种类型的纤颤均无预防作用。这些结果表明，利多卡因的抗纤颤作用可归因于药物引起的细胞电生理改变，而溴苄铵的抗纤颤作用则与此类变化无关。我们的研究提示，所报道的溴苄铵的抗纤颤能力与该药在交感神经末梢的作用有关，因此依赖于完整的交感神经系统。
