Asai Hospital, Togane, Japan.
Epilepsy Behav. 2013 May;27(2):342-5. doi: 10.1016/j.yebeh.2013.02.025. Epub 2013 Mar 27.
Treatment protocols for interictal psychosis (IIP) of patients with epilepsy have not yet been established. We aimed to clarify the effects of antipsychotic drugs (APDs) on duration of IIP episodes. We studied 393 IIP episodes in 200 patients with epilepsy in accordance with our empirical treatment protocol. The duration of all the episodes and APD treatments were reviewed. Antipsychotic drugs were used in 338 episodes and not used in 55 episodes (non-APD group). The APDs used in the treatment of IIP episodes were divided into the following three groups: first-generation APDs (FAPD, n=252), second-generation APDs (SAPD, n=44), and the combination of first- and second-generation APDs (CAPD, n=42). The non-APD group showed a significantly shorter episode duration than did the APD group (F=6.05, p=0.014). Among the 3 APD groups (FAPD, SAPD, and CAPD), there was a significant difference in duration of IIP episode (F=8.65, p=0.000). Whereas the duration of episodes was significantly longer in the CAPD group than in the other two groups, it was not significantly different between the FAPD and SAPD groups. Our findings further to clarify the nature of IIP and add further perspectives on treatment protocols for IIP.
癫痫患者发作间期精神病（IIP）的治疗方案尚未确定。我们旨在阐明抗精神病药物（APD）对 IIP 发作持续时间的影响。我们根据经验性治疗方案研究了 200 名癫痫患者的 393 个 IIP 发作。回顾了所有发作和 APD 治疗的持续时间。338 个发作中使用了抗精神病药物，55 个发作中未使用（非 APD 组）。用于治疗 IIP 发作的 APD 分为以下三组：第一代 APD（FAPD，n=252）、第二代 APD（SAPD，n=44）和第一代和第二代 APD 的组合（CAPD，n=42）。非 APD 组的发作持续时间明显短于 APD 组（F=6.05，p=0.014）。在 3 个 APD 组（FAPD、SAPD 和 CAPD）中，IIP 发作持续时间存在显著差异（F=8.65，p=0.000）。虽然 CAPD 组的发作持续时间明显长于其他两组，但 FAPD 和 SAPD 组之间没有显著差异。我们的研究结果进一步阐明了 IIP 的性质，并为 IIP 的治疗方案提供了更多的视角。
