West End Medical Associates, 617 West End Avenue, New York, NY 10024, USA.
Psychiatr Clin North Am. 2013 Mar;36(1):177-82. doi: 10.1016/j.psc.2013.01.007.
Age-associated hypothalamic-pituitary-gonadal (HPG) axis hypofunction, or partial androgen deficiency of the aging male, is thought to be responsible for various age-associated conditions such as reduced muscle and bone mass, mobility limitations, frailty, obesity, sleep apnea, cognitive impairment, sexual dysfunction, and depression. It has been difficult to establish consistent correlations between these symptoms and plasma testosterone levels in middle-aged men, but testosterone replacement does lead to improved muscle strength, bone density, and sexual function. This article focuses on the relationship between testosterone and mood in older men, and the treatment of age-related depression with exogenous testosterone.
年龄相关性下丘脑-垂体-性腺（HPG）轴功能减退，或中老年男性雄激素部分缺乏，被认为是导致各种与年龄相关的疾病的原因，如肌肉和骨量减少、活动能力受限、虚弱、肥胖、睡眠呼吸暂停、认知障碍、性功能障碍和抑郁。在中年男性中，很难确定这些症状与血浆睾酮水平之间的一致性相关性，但睾酮替代治疗确实可以改善肌肉力量、骨密度和性功能。本文重点关注老年男性睾酮与情绪之间的关系，以及外源性睾酮治疗与年龄相关的抑郁症。
