Department of Dermatology, Helsingborg Hospital, Clinical Sciences, Lund University, SE-251 87 Helsingborg, Sweden.
Acta Derm Venereol. 2013 May;93(3):305-8. doi: 10.2340/00015555-1560.
The aim of this study was to evaluate the accuracy of preoperative diagnosis of skin tumours in a dermatological setting. Patients undergoing skin surgery at the Department of Dermatology without preoperative biopsy were prospectively enrolled. Preoperatively, a single clinical diagnosis was registered. The histopathological diagnosis, performed after excision, was registered as the correct diagnosis. The sensitivity and positive predictive value of the clinical diagnosis were calculated. A total of 2,953 tumours were included. Altogether, 55.1% of the excised lesions were malignant. Excision margins for malignant tumours were free from tumour cells in 96.0% of cases. The sensitivity for diagnosis of malignant tumour was 98.0% and the positive predictive value was 85.3%. In line with previous studies, the sensitivity and positive predictive value were highest for basal cell carcinoma, 95.4% and 85.9%, respectively. For squamous cell carcinoma, the corresponding values were 68.0% and 67.3%, and for melanoma, 70.6% and 51.3%.
本研究旨在评估皮肤科环境下皮肤肿瘤术前诊断的准确性。在皮肤科行皮肤手术而无术前活检的患者被前瞻性纳入。术前记录了单一的临床诊断。切除后进行的组织病理学诊断被记录为正确诊断。计算了临床诊断的敏感性和阳性预测值。共纳入 2953 个肿瘤。总的来说，55.1%的切除病变为恶性。恶性肿瘤的切除边缘 96.0%无肿瘤细胞。恶性肿瘤诊断的敏感性为 98.0%，阳性预测值为 85.3%。与以往研究一致，基底细胞癌的敏感性和阳性预测值最高，分别为 95.4%和 85.9%。鳞状细胞癌的相应值分别为 68.0%和 67.3%，黑色素瘤分别为 70.6%和 51.3%。
