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本文引用的文献

1
Improving T₁ and T₂ magnetic resonance imaging contrast agents through the conjugation of an esteramide dendrimer to high-water-coordination Gd(III) hydroxypyridinone complexes.通过将酯酰胺树枝状大分子与高水配位 Gd(III) 羟吡啶酮配合物偶联来提高 T₁ 和 T₂ 磁共振成像对比剂的性能。
Contrast Media Mol Imaging. 2012 Jan-Feb;7(1):95-9. doi: 10.1002/cmmi.483.
2
Multivalent, high-relaxivity MRI contrast agents using rigid cysteine-reactive gadolinium complexes.使用刚性半胱氨酸反应性钆配合物的多价、高弛豫率 MRI 造影剂。
J Am Chem Soc. 2011 Sep 21;133(37):14704-9. doi: 10.1021/ja204516p. Epub 2011 Aug 26.
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Synthesis and properties of star-comb polymers and their doxorubicin conjugates.星型梳状聚合物及其阿霉素缀合物的合成与性能。
Bioconjug Chem. 2011 Apr 20;22(4):617-24. doi: 10.1021/bc100400u. Epub 2011 Mar 4.
4
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Chem Biol Drug Des. 2011 May;77(5):388-92. doi: 10.1111/j.1747-0285.2011.01103.x. Epub 2011 Mar 25.
5
Conjugation effects of various linkers on Gd(III) MRI contrast agents with dendrimers: optimizing the hydroxypyridinonate (HOPO) ligands with nontoxic, degradable esteramide (EA) dendrimers for high relaxivity.各种连接子对树枝状大分子 Gd(III)MRI 造影剂的偶联效应：用低毒、可降解的酯酰胺（EA）树枝状大分子优化羟吡咯啉酮（HOPO）配体以获得高弛豫率。
J Am Chem Soc. 2011 Mar 2;133(8):2390-3. doi: 10.1021/ja110582e. Epub 2011 Feb 4.
6
Dual-surface modified virus capsids for targeted delivery of photodynamic agents to cancer cells.双表面修饰的病毒衣壳用于向癌细胞靶向递送光动力药物。
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Eu(III) Complexes of Octadentate 1-Hydroxy-2-pyridinones: Stability and Improved Photophysical Performance[].八齿1-羟基-2-吡啶酮的铕（III）配合物：稳定性及改善的光物理性能
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1-Methyl-3-hydroxy-pyridin-2-one complexes of near infra-red emitting lanthanides: efficient sensitization of Yb(III) and Nd(III) in aqueous solution.近红外发光镧系元素 1-甲基-3-羟基-2-吡啶酮配合物：水溶液中 Yb(III)和 Nd(III)的有效敏化。
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Gd(III)-nanodiamond conjugates for MRI contrast enhancement.钆(III)-纳米金刚石缀合物用于磁共振成像对比增强。
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与生物相容性树枝状聚合物的共轭增加了用于磁共振成像（MRI）的羟基吡啶酮（HOPO）配合物的镧系元素弛豫率。

Conjugation to Biocompatible Dendrimers Increases Lanthanide Relaxivity of Hydroxypyridinone (HOPO) Complexes for Magnetic Resonance Imaging (MRI).

作者信息

Klemm Piper J, Floyd William C, Andolina Christopher M, Fréchet Jean M J, Raymond Kenneth N

机构信息

Department of Chemistry, University of California, Berkeley, Berkeley, California 94720 United States.

出版信息

Eur J Inorg Chem. 2012 Apr;2012(12):2108-2114. doi: 10.1002/ejic.201101167.

DOI:10.1002/ejic.201101167
PMID:23539072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3607537/
Abstract

Magnetic resonance imaging (MRI) contrast agents represent a worldwide billion-dollar market annually. While relaxivity enhancement contrast agents receive greater attention and a significantly larger market share, the commercial potential for relaxivity enhancing contrast agents remains a viable diagnostic option due to their increased relaxivity at high field strengths. Improving the contrast and biocompatibility of MRI probes may enable new diagnostic prospects for MRI. Paramagnetic lanthanides have the potential to decrease and proton relaxation times, but are not commercially used in MRI diagnostics as agents. In this article, oxygen donor chelates (hydroxypyridinone, HOPO, and terephthalamide, TAM) of various lanthanides are demonstrated as biocompatible macromolecular dendrimer conjugates for the development of MRI probes. These conjugates have relaxivities up to 374 mms per dendrimer, high bioavailability, and low toxicity.

摘要

磁共振成像（MRI）造影剂每年在全球的市场规模达数十亿美元。虽然弛豫率增强型造影剂受到了更多关注且占据了显著更大的市场份额，但由于其在高场强下弛豫率的增加，弛豫率增强型造影剂的商业潜力仍是一种可行的诊断选择。改善MRI探针的对比度和生物相容性可能为MRI带来新的诊断前景。顺磁性镧系元素有降低 和质子弛豫时间的潜力，但未作为造影剂在MRI诊断中商业化使用。在本文中，各种镧系元素的氧供体螯合物（羟基吡啶酮，HOPO，和对苯二甲酰胺，TAM）被证明是用于开发MRI探针的生物相容性大分子树枝状聚合物共轭物。这些共轭物每个树枝状聚合物的弛豫率高达374 mms，具有高生物利用度和低毒性。