钆(III)-纳米金刚石缀合物用于磁共振成像对比增强。
Gd(III)-nanodiamond conjugates for MRI contrast enhancement.
机构信息
Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, USA.
出版信息
Nano Lett. 2010 Feb 10;10(2):484-9. doi: 10.1021/nl903264h.
Abstract
A Gd(III)-nanodiamond conjugate [Gd(III)-ND] was prepared and characterized, enabling detection of nanodiamonds by MR imaging. The Gd(III)-ND particles significantly reduced the T(1) of water protons with a per-Gd(III) relaxivity of 58.82 +/- 1.18 mM(-1) s(-1) at 1.5 T (60 MHz). This represents a 10-fold increase compared to the monomer Gd(III) complex (r(1) = 5.42 +/- 0.20 mM(-1) s(-1)) and is among the highest per-Gd(III) relaxivities reported.
摘要
制备并表征了一种 Gd(III)-纳米金刚石缀合物 [Gd(III)-ND]，通过磁共振成像可检测纳米金刚石。Gd(III)-ND 颗粒显著降低了水质子的 T(1)，在 1.5 T（60 MHz）下每个 Gd(III)的弛豫率为 58.82 +/- 1.18 mM(-1) s(-1)。与单体 Gd(III)配合物 (r(1) = 5.42 +/- 0.20 mM(-1) s(-1)) 相比，这增加了 10 倍，是报道的最高每 Gd(III)弛豫率之一。
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