高剂量，低饱和度：慢性合成大麻素使用相关的弥漫性肺部浸润。
High times, low sats: diffuse pulmonary infiltrates associated with chronic synthetic cannabinoid use.
机构信息
UCSF-Fresno Medical Center, Fresno, CA, USA.
出版信息
J Med Toxicol. 2013 Jun;9(2):199-206. doi: 10.1007/s13181-013-0288-9.
INTRODUCTION
In recent years, cases of severe adverse effects from recreational use of synthetic cannabinoids (SC) have established that these agents represent a novel toxicologic hazard.
CASE REPORT
A 21-year-old male presenting as a vehicular trauma victim was noted with diffuse pulmonary infiltrates related to chronic inhalation of multiple synthetic cannabinoid-containing products. Chest imaging revealed bilateral, subacute lung infiltrates; histopathological analysis of bronchial and alveolar tissues revealed an inflammatory process. An extensive workup failed to identify infectious, malignant, autoimmune, or hematologic causes of the syndrome, and toxicological analysis of the blood and body fluids confirmed the presence of multiple synthetic cannabinoids and metabolites. The patient recovered after an 8-day ICU course, wherein he received antibiotics, steroids, and mechanical ventilation.
DISCUSSION
This case contributes to the currently evolving knowledge about SC agents, adding a rarely described pulmonary complication to the growing list of adverse effects associated with these products.
简介
近年来，娱乐性使用合成大麻素（SC）导致严重不良后果的案例表明，这些物质代表了一种新的毒理学危害。
病例报告
一名 21 岁男性，作为车祸受害者就诊，其弥漫性肺浸润与慢性吸入多种含有合成大麻素的产品有关。胸部影像学显示双侧亚急性肺部浸润；支气管和肺泡组织的组织病理学分析显示炎症过程。广泛的检查未能确定该综合征的感染、恶性、自身免疫或血液学原因，血液和体液的毒理学分析证实存在多种合成大麻素和代谢物。患者在 ICU 接受了 8 天的治疗后康复，期间接受了抗生素、类固醇和机械通气。
讨论
该病例丰富了人们对 SC 药物的认识，除了越来越多的与这些产品相关的不良影响之外，还增加了一种罕见描述的肺部并发症。
Zotero 插件