Yasmeen B H N, Chowdhury M A K A, Hoque M M, Hossain M M, Jahan R, Akhtar S
Department of Pediatrics, Northern International Medical College, Dhanmondi, Dhaka.
Bangladesh Med Res Counc Bull. 2012 Dec;38(3):119-23. doi: 10.3329/bmrcb.v38i3.14340.
Premature infants especially those with birth weight < 1500 g suffer from Anaemia of prematurity (AOP) and associated problems. Erythropoietin therapy is a safe effective way to prevent and to treat anaemia of prematurity. To evaluate the effect of short-term administration of recombinant human erythropoietin (rHuEPO) with iron and folic acid in very low birth weight (VLBW) neonates in the prevention of anaemia of prematurity. A randomized controlled trial was carried out at Dhaka Shishu Hospital. Sixty preterm very low birth weight (PTVLBW) babies were enrolled in this study. Thirty were assigned to rHuEPO group and 30 as control. Baseline haematologic values were estimated before administration of rHuEPO. From day 7 of life rHuEPO-200 IU/kg/dose subcutaneously every alternate day for 2 weeks was administered to rHuEPO group. All infants in both groups have received oral iron, folic acid from day 14. Clinical and haematological assessment was done at 6 and 10 weeks of life. Baseline clinical characteristics and haematologic values were almost similar in both groups. This study has shown increase in haematological values (haemoglobin and haematocrit) and reduction in the number of blood transfusions during both the 1st and 2nd follow up in rHuEPO group in comparison to control group (p < 0.01). Short-term rHuEPO appears to be very effective in prevention of Anaemia of prematurity.
早产儿尤其是出生体重<1500克的婴儿易患早产儿贫血（AOP）及相关问题。促红细胞生成素治疗是预防和治疗早产儿贫血的一种安全有效的方法。为评估短期给予重组人促红细胞生成素（rHuEPO）联合铁剂和叶酸对极低出生体重（VLBW）新生儿预防早产儿贫血的效果。在达卡儿童医院进行了一项随机对照试验。本研究纳入了60例早产极低出生体重（PTVLBW）婴儿。30例被分配到rHuEPO组，30例作为对照组。在给予rHuEPO之前评估基线血液学值。从出生第7天起，rHuEPO组每隔日皮下注射200 IU/kg/剂量，共2周。两组所有婴儿从第14天起均接受口服铁剂、叶酸。在出生6周和10周时进行临床和血液学评估。两组的基线临床特征和血液学值几乎相似。本研究表明，与对照组相比，rHuEPO组在第1次和第2次随访期间血液学值（血红蛋白和血细胞比容）升高，输血次数减少（p<0.01）。短期rHuEPO似乎对预防早产儿贫血非常有效。
