Institute for Knowledge Discovery, Graz University of Technology, Inffeldgasse 13/4, A-8010 Graz, Austria.
Clin Neurophysiol. 2013 Aug;124(8):1596-604. doi: 10.1016/j.clinph.2013.02.019. Epub 2013 Mar 26.
We studied the activation of cortical motor and parietal areas during the observation of object related grasping movements. By manipulating the type of an object (realistic versus abstract) and the type of grasping (correct versus incorrect), we addressed the question how observing such object related movements influences cortical rhythmicity, especially the mu-rhythm, in the context of an "extended" human mirror neuron system (MNS).
Multichannel electroencephalogram (EEG) was recorded during the observation of different object-related grasping actions in twenty healthy subjects. Different movies were presented, showing sequences of correct or incorrect hand grasping actions related to an abstract or realistic (daily life) object.
Event-related de/synchronization (ERD/ERS) analyses revealed a larger ERD in the upper alpha (10-12 Hz), beta (16-20 Hz) and gamma (36-40 Hz) frequency bands over parietal brain regions depending on the type of grasping. The type of object only influenced ERD patterns in the gamma band range (36-40 Hz) at parietal sites suggesting a strong relation of gamma band activity and cortical object representation. Abstract and realistic objects produced lower beta band synchronization at central sites only, whereas depending on the type of grasping an ERS in the upper alpha band (10-12 Hz) was observed.
Depending on the type of the grasped object and the type of grasping stronger parietal cortical activation occurred during movement observation.
Discussing the results in terms of an "extended" human mirror neuron system (MNS), it could be concluded that beside sensorimotor areas a stronger involvement of parietal brain regions was found depending on the type of object and grasping movement observed.
我们研究了在观察与物体相关的抓握运动时皮质运动和顶叶区域的激活情况。通过操纵物体的类型（真实与抽象）和抓握的类型（正确与错误），我们提出了一个问题，即在“扩展”的人类镜像神经元系统（MNS）背景下，观察此类与物体相关的运动如何影响皮质节律性，特别是 mu 节律。
在二十名健康受试者观察不同与物体相关的抓握动作期间，记录了多通道脑电图（EEG）。呈现了不同的电影，展示了与抽象或真实（日常生活）物体相关的正确或错误手抓握动作序列。
事件相关去同步/同步（ERD/ERS）分析显示，取决于抓握的类型，顶叶脑区的上 alpha（10-12 Hz）、beta（16-20 Hz）和 gamma（36-40 Hz）频段的 ERD 更大。物体的类型仅在伽马频段（36-40 Hz）影响顶叶部位的 ERD 模式，表明伽马频段活动与皮质物体表示之间存在很强的关系。抽象和真实物体仅在中央部位产生较低的 beta 频段同步，而取决于抓握的类型，在上 alpha 频段（10-12 Hz）观察到 ERS。
取决于所抓握物体的类型和抓握的类型，在运动观察期间会发生更强的顶叶皮质激活。
根据“扩展”的人类镜像神经元系统（MNS）讨论结果，可以得出结论，除了感觉运动区域外，还发现取决于观察到的物体类型和抓握运动，顶叶脑区的参与更强。
