Denecke Kerstin, Spreckelsen Cord
Universitätsmedizin Göttingen, Göttingen, Germany.
Stud Health Technol Inform. 2013;186:41-5.
Advances in genomics and human genetics have enabled a more detailed understanding of the impact of genetics in a disease and its treatment. In addition to a patient's clinical signs and symptoms, physicians can now or in near future consider genetic data for their diagnosis and treatment decisions. This new information source based on genome and gene expression analysis makes clinical decision processes even more complex. Beyond, behavioral and environmental aspects should also be considered in order to realize personalized medicine. Given these additional information sources, the need for support in decision making is increasing. In this paper, we introduce a vision how knowledge-based systems or decision support systems can help to realize personalized medicine and we explore the upcoming challenges for clinical decision support in that context.
基因组学和人类遗传学的进展使人们能够更详细地了解遗传学在疾病及其治疗中的影响。除了患者的临床体征和症状外，医生现在或在不久的将来可以在诊断和治疗决策中考虑基因数据。这种基于基因组和基因表达分析的新信息来源使临床决策过程更加复杂。此外，为了实现个性化医疗，还应考虑行为和环境因素。鉴于这些额外的信息来源，决策支持的需求正在增加。在本文中，我们提出了一个愿景，即基于知识的系统或决策支持系统如何能够帮助实现个性化医疗，并探讨在这种背景下临床决策支持即将面临的挑战。
