Williams A R, Beaulaurier K E, Seal D L
Pain Consultation Service, Swedish Hospital Medical Center, Seattle, WA 98104.
Cancer Nurs. 1990 Jun;13(3):176-82. doi: 10.1097/00002820-199006000-00007.
Chronic epidural administration of narcotics and/or local anesthetics is sometimes required in those few patients where utilization of systemic narcotics and appropriate adjuvant medications is unsuccessful in controlling intractable cancer pain. The Du Pen epidural catheter (Davol, Inc.) a silicone-based tunneled catheter modeled after the Hickman central venous catheter, has provided a safe, reliable means of long-term administration of drugs to the epidural space in over 400 patients to date. A systematic approach to the pharmacology of epidural pain control includes drug choice, bolus dosing versus infusion, volume guidelines, and titration protocols. Utilization of local anesthetics in combination with narcotics allows for enhanced pain relief in those patients refractory to narcotics as is frequently the case with neurogenic involvement. Follow-up care of patients receiving epidural narcotic with or without local anesthetic can be accomplished by a trained home cae team. Successful epidural pain management requires thorough patient and caregiver education, frequent pain assessment, and monitoring of side effects, with close collaboration between patient/family, pharmacist, home care nurse, and physician.
对于少数患者,当使用全身性麻醉药和适当的辅助药物无法有效控制顽固性癌症疼痛时,有时需要长期硬膜外给予麻醉药和/或局部麻醉药。杜彭硬膜外导管(Davol公司)是一种以希克曼中心静脉导管为模型的硅胶隧道式导管,迄今为止,已为400多名患者提供了一种安全、可靠的向硬膜外间隙长期给药的方法。硬膜外疼痛控制药理学的系统方法包括药物选择、推注给药与输注、容量指南和滴定方案。在经常伴有神经源性受累的情况下,将局部麻醉药与麻醉药联合使用可增强对麻醉药耐受的患者的疼痛缓解效果。接受硬膜外麻醉药(无论是否联合局部麻醉药)治疗的患者的后续护理可由经过培训的家庭护理团队完成。成功的硬膜外疼痛管理需要对患者和护理人员进行全面教育、频繁进行疼痛评估并监测副作用,患者/家属、药剂师、家庭护理护士和医生之间要密切协作。