Buisson Rémi, Masson Jean-Yves
Genome stability laboratory, Laval university cancer research center, Hôtel-Dieu de Quebec research center (CHUQ), 9 McMahon, Québec, G1R 2J6, Canada.
Med Sci (Paris). 2013 Mar;29(3):301-7. doi: 10.1051/medsci/2013293017. Epub 2013 Mar 27.
Cancer is now the leading cause of mortality in France. It has been clearly demonstrated that mutations in the genetic information is the initiating event of cancer. DNA damage such as DNA double-strand breaks leads to genomic instability and cancer development. Cells can repair DNA double-strand breaks through several mechanisms. Nevertheless, only homologous recombination repair is faithful and repairs DNA without creating mutations. Here, we review the roles of PALB2 and BRCA2 in homologous recombination and genome stability.
癌症目前是法国的主要死因。已经明确证明，遗传信息中的突变是癌症的起始事件。诸如DNA双链断裂之类的DNA损伤会导致基因组不稳定和癌症发展。细胞可以通过多种机制修复DNA双链断裂。然而，只有同源重组修复是准确无误的，并且在修复DNA时不会产生突变。在此，我们综述了PALB2和BRCA2在同源重组和基因组稳定性中的作用。
