Liu Yiqun, Xiong Jing, He Honghui, Zhu Shaihong, Mo Zhaohui
Department of Endocrinology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Mar;38(3):258-61. doi: 10.3969/j.issn.1672-7347.2013.03.007.
To investigate the change in serum visfatin level after laparoscopic Roux-en-Y gastric bypass surgery in patients with Type 2 diabetes mellitus (T2DM) and to explore the relationship between visfatin insulin resistance and diabetes.
Thirty-three patients with Type 2 diabetes were studied before and after the gastric bypass surgery. The level of fasting serum visfatin was measured by enzyme-linked immunosorbent assay. Fasting plasma glucose (FPG), glycated hemoglobin (HbA1c) and fasting insulin (FINS) were measured before and after the gastric bypass surgery.
Compared with before the operation, the indicators of HbA1c, FINS, and insulin resistance index (HOMA-IR) were decreased after the laparoscopic Roux-en-Y gastric bypass surgery. The body mass index (BMI) [(24.53 ± 0.62) kg/m² vs (26.71 ± 0.69) kg/m2] was decreased, with significant difference (P<0.001). The serum visfatin level [(9.79 ± 0.64) ng/mL] was significantly lower than before the operation [(38.24 ± 5.32) ng/mL], with significant difference (P<0.001).
Serum level of visfatin is decreased in T2DM patients who undergo gastric bypass surgry, reflecting an improvement in insulin resistance and diabetes.
探讨2型糖尿病（T2DM）患者行腹腔镜Roux-en-Y胃旁路手术后血清内脂素水平的变化，并探讨内脂素与胰岛素抵抗及糖尿病之间的关系。
对33例2型糖尿病患者在胃旁路手术前后进行研究。采用酶联免疫吸附测定法检测空腹血清内脂素水平。在胃旁路手术前后测量空腹血糖（FPG）、糖化血红蛋白（HbA1c）和空腹胰岛素（FINS）。
与手术前相比，腹腔镜Roux-en-Y胃旁路手术后HbA1c、FINS及胰岛素抵抗指数（HOMA-IR）指标均降低。体重指数（BMI）[（24.53±0.62）kg/m² 对（26.71±0.69）kg/m²]降低，差异有统计学意义（P<0.001）。血清内脂素水平[（9.79±0.64）ng/mL]显著低于手术前[（38.24±5.32）ng/mL]，差异有统计学意义（P<0.001）。
接受胃旁路手术的T2DM患者血清内脂素水平降低，反映胰岛素抵抗和糖尿病有所改善。
