Sokolov E I, Grishina T I, Shtin S R
Kardiologiia. 2013;53(3):25-30.
In 44 patients with ischemic heart disease (IHD) and 35 healthy subjects we studied cascade mechanism of platelets activation by von Willebrand factor (vWF), and interrelationship of platelet aggregation, level of vWF, and endothelial dysfunction. The latter was estimated by severity of vasoconstriction determined basing on endothelin-1 levels. Quantitative assessment of platelet aggregation revealed differences in aggregation capacity between healthy subjects and patients with IHD. Of particular importance was absence of spontaneous aggregation in healthy subjects. It was shown that in IHD patients influence of vWF resulted in augmentation and convergence of activating signal. Positive correlation was found in patients with IHD between elevation of levels of vWF, endothelin-1, and spontaneous and induced platelet aggregation activity. Interrelationship was revealed between character of IHD course and degree of elevation of the studied markers.
在44例缺血性心脏病（IHD）患者和35名健康受试者中，我们研究了血管性血友病因子（vWF）激活血小板的级联机制，以及血小板聚集、vWF水平和内皮功能障碍之间的相互关系。后者通过基于内皮素-1水平测定的血管收缩严重程度来评估。血小板聚集的定量评估显示健康受试者和IHD患者之间的聚集能力存在差异。特别重要的是健康受试者不存在自发聚集。结果表明，在IHD患者中，vWF的影响导致激活信号增强和汇聚。在IHD患者中发现vWF水平升高、内皮素-1水平升高与自发和诱导的血小板聚集活性之间呈正相关。揭示了IHD病程特征与所研究标志物升高程度之间的相互关系。
