Fredericks C M, Anderson G F, Kreulen D L
Invest Urol. 1975 Jan;12(4):317-9.
Experiments have been conducted which show that while the tertiary amine oxybutynin has only moderate in vitro anticholinergic and antihistaminic activity, it is a potent inhibitor of barium chloride-induced spasms of rabbit detrusor muscle. Oxybutynin exerts 1/13 the anticholinergic activity of propantheline and 1/4 that of atropine, but produces approximately 2x the inhibition of barium chloride-induced spasm than propantheline and 10x the inhibition produced by atropine. In sum, oxybutynin possesses a notable antispasmodic activity distinct from its anticholinergic activity and stronger than that of atropine, propantheline, or methantheline, which may prove useful in the treatment of smooth muscle hypermotility.
已进行的实验表明，虽然叔胺奥昔布宁仅具有中等程度的体外抗胆碱能和抗组胺活性，但它是氯化钡诱导的兔逼尿肌痉挛的有效抑制剂。奥昔布宁的抗胆碱能活性仅为丙胺太林的1/13和阿托品的1/4，但对氯化钡诱导的痉挛的抑制作用约为丙胺太林的2倍，阿托品的10倍。总之，奥昔布宁具有明显的抗痉挛活性，与其抗胆碱能活性不同，且比阿托品、丙胺太林或美索曲明更强，这可能在治疗平滑肌运动亢进方面有用。
