Güdücü N, Gönenç G, Işçi H, Yiğiter A Başgül, Dünder I
Department of Obstetrics and Gynecology, Avrupa Hospital, Istanbul Bilim University, Istanbul, Turkey.
J Obstet Gynaecol. 2013 Apr;33(3):269-71. doi: 10.3109/01443615.2012.759915.
The aim of this study was to investigate the role of quadruple test parameters in predicting the risk of delivering a small for gestational age (SGA) infant. The quadruple test results of patients performed at 16-18 weeks of pregnancy were searched retrospectively. Alpha-fetoprotein (AFP) levels higher than 2 MoM were associated with a risk of delivering an SGA infant (p = 0.025), sensitivity 8%, specificity 98%, positive predictive value 25%, negative predictive value 91%. Other quadruple test parameters were not related to delivery of an SGA infant. The introduction of AFP as a screening test for the detection of SGA infants does not seem feasible, but we suggest clinicians take it into account when counselling the patients about the results of Down syndrome screening tests.
本研究的目的是调查四联试验参数在预测小于胎龄（SGA）儿分娩风险中的作用。回顾性检索了妊娠16 - 18周时进行的患者四联试验结果。甲胎蛋白（AFP）水平高于2倍中位数（MoM）与分娩SGA儿的风险相关（p = 0.025），敏感性8%，特异性98%，阳性预测值25%，阴性预测值91%。其他四联试验参数与SGA儿分娩无关。将AFP作为检测SGA儿的筛查试验引入似乎不可行，但我们建议临床医生在为患者提供唐氏综合征筛查试验结果咨询时考虑这一点。
