Venter C P, Joubert P H, Venter H L, Muntingh G L, du Plooy W J
Department of Pharmacology and Therapeutics, Medical University of Southern Africa, Medunsa.
J Clin Pharmacol. 1990 Jun;30(6):533-7. doi: 10.1002/j.1552-4604.1990.tb03616.x.
The antihypertensive effects of penbutolol, a nonselective beta-adrenoceptor antagonist with intrinsic sympathomimetic activity, was assessed in nonobese black South Africans aged 25 to 65 years with uncomplicated mild to moderate essential hypertension. After a 4-week placebo run-in period 50 patients entered a randomized placebo-controlled study with a crossover design. For 8 weeks they received a once daily dose of 40 mg penbutolol (or placebo) which was increased to 80 mg per day for the next 4 weeks in poor responders. This was followed by a 4-week placebo washout period after which a crossover of treatment was achieved and a second 12-week period of treatment initiated. Thirty-five patients completed the whole study and in 15 patients diastolic blood pressure was reduced below 95 mm Hg. The mean systolic pressures of these patients decreased by 21 mm Hg and their mean diastolic pressure decreased by 11 mm Hg during treatment with penbutolol. These results suggest that penbutolol monotherapy is an alternative therapeutic approach to hypertension in black South Africans.
对苯丁心安（一种具有内在拟交感活性的非选择性β肾上腺素能受体拮抗剂）在年龄为25至65岁、患有单纯性轻度至中度原发性高血压的非肥胖南非黑人中的降压效果进行了评估。在为期4周的安慰剂导入期后，50名患者进入了一项采用交叉设计的随机安慰剂对照研究。在8周时间里，他们每日服用一次40毫克苯丁心安（或安慰剂），对于反应欠佳者，在接下来的4周中将剂量增至每日80毫克。之后是为期4周的安慰剂洗脱期，在此之后实现治疗交叉并开始第二个为期12周的治疗阶段。35名患者完成了整个研究，15名患者的舒张压降至95毫米汞柱以下。在用苯丁心安治疗期间，这些患者的平均收缩压下降了21毫米汞柱，平均舒张压下降了11毫米汞柱。这些结果表明，苯丁心安单药治疗是南非黑人高血压的一种替代治疗方法。
