Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Cambridge, United Kingdom.
Ann N Y Acad Sci. 2013 Mar;1280:24-6. doi: 10.1111/nyas.12027.
Mammalian cells can express up to four different class I phosphatidylinositide 3-kinase (PI3K) isoforms, each of which is engaged by tyrosine kinases or G protein-coupled receptors (GPCRs) to generate the second messenger signaling molecule PtdIns(3,4,5)P₃ (PIP₃). The p110α and p110β isoforms are relatively widely expressed, whereas p110γ and p110δ are more highly expressed in cells of the immune system than in other cell types. Nevertheless, each of the four class I PI3Ks have been shown to participate in the orchestration of the signaling events that lead to immune cell development and control of gene expression, skewing toward individual cell lineage subsets and proliferation.
哺乳动物细胞可以表达多达四种不同的 I 类磷酸肌醇 3-激酶 (PI3K) 同工型，每种同工型都被酪氨酸激酶或 G 蛋白偶联受体 (GPCR) 募集，以生成第二信使信号分子 PtdIns(3,4,5)P₃ (PIP₃)。p110α 和 p110β 同工型表达较为广泛，而 p110γ 和 p110δ 在免疫系统细胞中的表达高于其他细胞类型。然而，已经证明四种 I 类 PI3K 中的每一种都参与了信号事件的协调，这些信号事件导致免疫细胞的发育和基因表达的控制，偏向于单个细胞谱系亚群和增殖。
