Ohkubo Yu, Kato Shingo, Kiyohara Hiroki, Suzuki Yoshiyuki, Nakano Takashi, Kamada Tadashi
Department of Radiology, Saitama Cancer Center, Ina, Kita-adachi, Saitama, Japan.
J Obstet Gynaecol Res. 2013 May;39(5):1111-5. doi: 10.1111/jog.12024. Epub 2013 Apr 4.
Granulocyte-colony stimulating factor (G-CSF)-producing tumor is a rare condition. It has an aggressive nature and shows resistance to conventional treatments. We report two cases of G-CSF-producing uterine cervical cancer who were successfully treated with carbon-ion radiotherapy (C-ion RT). The first case was a 76-year-old woman with stage IIIB uterine cervical cancer, and the second was a 75-year-old woman with bulky stage IIB disease. Prior to treatment, both patients presented severe granulocytosis and elevated serum G-CSF concentrations. After C-ion RT, their cervical tumors completely disappeared, and their granulocytosis and elevated serum G-CSF levels improved as well. C-ion RT has been reported to be effective for various aggressive tumors, and it may be a good treatment option for this rare aggressive tumor.
