Watt G, Padre L P, Tuazon M, Calubaquib C
Naval Medical Research Unit Number 2, Manila, Philippines.
J Infect Dis. 1990 Jul;162(1):266-9. doi: 10.1093/infdis/162.1.266.
Information is lacking on the prevalence and severity of cardiac and striated muscle injury in late leptospirosis, and it is unclear whether patients with one type of myositis are at increased risk of developing another. Therefore, 38 patients with severe, late Weil's disease were evaluated for heart and skeletal muscle involvement: 37% had myositis and 39% had abnormal electrocardiograms (ECGs). First-degree atrioventricular heart block and changes suggestive of acute pericarditis were the most common ECG findings. Two patients had transient pericardial friction rubs, but neither pericardial effusion, shock, nor congestive heart failure occurred. Cardiac involvement was not associated with skeletal muscle injury (P = .35), although both manifestations were correlated with severity of disease. Thus, ECG changes and myositis were prominent features of late Weil's disease but cardiac morbidity was not.
关于钩端螺旋体病晚期心脏和横纹肌损伤的患病率及严重程度的信息尚缺乏，且一种类型的肌炎患者发生另一种肌炎的风险是否增加尚不清楚。因此，对38例严重的钩端螺旋体病晚期患者进行了心脏和骨骼肌受累情况评估：37%有肌炎，39%有异常心电图（ECG）。一度房室传导阻滞和提示急性心包炎的改变是最常见的心电图表现。2例患者有短暂的心包摩擦音，但均未发生心包积液、休克或充血性心力衰竭。心脏受累与骨骼肌损伤无关（P = 0.35），尽管两种表现均与疾病严重程度相关。因此，心电图改变和肌炎是钩端螺旋体病晚期的突出特征，但心脏发病率并非如此。
