Nadol J B
Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts.
J Electron Microsc Tech. 1990 Jun;15(2):187-96. doi: 10.1002/jemt.1060150210.
Innervations of inner and outer hair cells of the organ of Corti of the human cochlea were studied by serial section electron microscopy. At the base of inner hair cells, presumed afferent fibers were of varying size and demonstrated synaptic specialization consisting of a presynaptic body, vesicles, and asymmetrical synaptic membrane specialization. Two types of neurons, vesiculated presumably efferent and nonvesiculated presumably afferent, synapsed at the base of outer hair cells. The synaptic specialization of afferent fibers included presynaptic body, vesicles, and asymmetrical membrane thickening, whereas efferent synapses demonstrated presynaptic vesicles and a subsynaptic cisterna. Some presumably afferent nerve terminals formed a reciprocal synapse with outer hair cells in both the human and the chimpanzee. Such a synaptic relationship demonstrated morphologic specialization consistent with both hair cell-to-neuron and neuron-to-hair cell transmission between the same outer hair cell and nerve terminal. The innervation density of inner and outer hair cells and the comparative anatomy of the afferent and efferent innervation are discussed.
通过连续切片电子显微镜研究了人类耳蜗柯蒂氏器内、外毛细胞的神经支配。在内毛细胞基部，推测的传入纤维大小各异，并表现出突触特化，包括突触前体、囊泡和不对称的突触膜特化。两种类型的神经元，即推测为传出的含囊泡神经元和推测为传入的不含囊泡神经元，在外毛细胞基部形成突触。传入纤维的突触特化包括突触前体、囊泡和不对称的膜增厚，而传出突触则表现出突触前囊泡和突触下池。在人类和黑猩猩中，一些推测为传入的神经末梢与外毛细胞形成了交互突触。这种突触关系显示出形态学特化，与同一外毛细胞和神经末梢之间的毛细胞到神经元以及神经元到毛细胞的传递相一致。讨论了内、外毛细胞的神经支配密度以及传入和传出神经支配的比较解剖学。
