Center for AIDS Intervention Research, Medical College of Wisconsin, 2071 N. Summit Ave., Milwaukee, WI 53202, USA.
AIDS Behav. 2013 Jul;17(6):2031-44. doi: 10.1007/s10461-013-0469-1.
This study describes the results of an online social support intervention, called "Thrive with Me" (TWM), to improve antiretroviral therapy (ART) adherence. HIV-positive gay or bisexually-identified men self-reporting imperfect ART adherence in the past month were randomized to receive usual care (n = 57) or the eight-week TWM intervention (n = 67). Self-reported ART outcome measures (0-100 % in the past month) were collected at baseline, post-intervention, and 1-month follow-up. Follow-up assessment completion rate was 90%. Participants rated (1-7 scale) the intervention high in information and system quality and overall satisfaction (Means ≥ 5.0). The intervention showed modest effects for the overall sample. However, among current drug-using participants, the TWM (vs. Control) group reported significantly higher overall ART adherence (90.1 vs. 57.5% at follow-up; difference = 31.1, p = 0.02) and ART taken correctly with food (81.6 vs. 55.7% at follow-up; difference = 47.9, p = 0.01). The TWM intervention appeared feasible to implement, acceptable to users, and demonstrated greatest benefits for current drug users.
本研究描述了一项名为“与我一起成长”（TWM）的在线社会支持干预措施的结果，旨在提高抗逆转录病毒疗法（ART）的依从性。自我报告过去一个月存在不完美 ART 依从性的 HIV 阳性男同性恋或双性恋男性，随机分为接受常规护理组（n = 57）或接受为期八周的 TWM 干预组（n = 67）。在基线、干预后和 1 个月随访时收集自我报告的 ART 结果测量（过去一个月的 0-100%）。随访评估完成率为 90%。参与者（1-7 分制）对干预的信息和系统质量以及总体满意度评价较高（平均值≥5.0）。该干预对总体样本显示出适度的效果。然而，在当前使用药物的参与者中，TWM（与对照组相比）组报告的总体 ART 依从性显著更高（随访时为 90.1% vs. 57.5%；差异=31.1，p=0.02），并且正确随餐服用 ART 的比例也更高（随访时为 81.6% vs. 55.7%；差异=47.9，p=0.01）。TWM 干预措施似乎易于实施，用户接受度高，并且对当前药物使用者的益处最大。
