7-T MRI 脊髓成像可检测肌萎缩侧索硬化症中的皮质脊髓侧束异常。
7-T MRI of the spinal cord can detect lateral corticospinal tract abnormality in amyotrophic lateral sclerosis.
机构信息
AA Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
出版信息
Muscle Nerve. 2013 May;47(5):760-2. doi: 10.1002/mus.23720. Epub 2013 Mar 29.
INTRODUCTION
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting lower and upper motor neurons. Degeneration of the lateral corticospinal tract (CST) is a key finding in ALS cervical spinal cord autopsies. We hypothesized that in vivo ultra-high-field MRI of the cervical spinal cord can detect abnormality in the CST.
METHODS
A patient with ALS (disease duration 23 months) and a healthy control were scanned at 7-T MRI using a 19-channel coil. Multi-echo T2*-weighted imaging was performed in the spinal cord, covering C2-C6. Cross-sectional resolution was 0.37 × 0.37 mm(2).
RESULTS
We detected clear signal hyperintensity in both segments of the lateral CST in the ALS patient, which was significant when compared with the normal control subject (P < 10(-7)).
CONCLUSION
We believe there are potential benefits of 7-T MRI for increased sensitivity and spatial accuracy in characterizing pathology in the spinal cord.
简介
肌萎缩侧索硬化症（ALS）是一种影响上下运动神经元的进行性神经退行性疾病。外侧皮质脊髓束（CST）的变性是 ALS 颈椎脊髓尸检的一个重要发现。我们假设颈椎脊髓的超高场 MRI 活体检查可以检测 CST 的异常。
方法
使用 19 通道线圈，在 7-T MRI 上对一名 ALS 患者（病程 23 个月）和一名健康对照者进行扫描。在脊髓中进行多回波 T2*-加权成像，覆盖 C2-C6。横截面分辨率为 0.37×0.37mm²。
结果
我们在 ALS 患者的外侧 CST 两个节段均检测到明显的信号高信号，与正常对照组相比具有统计学意义（P＜10（-7））。
结论
我们认为 7-T MRI 具有更高的敏感性和空间准确性，有助于更好地描述脊髓病变，具有潜在的益处。
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