AntiCancer, Inc., San Diego, California, USA.
J Cell Biochem. 2013 Sep;114(9):2131-7. doi: 10.1002/jcb.24561.
Pancreatic cancer is highly treatment-resistant and has one of the highest fatality rates of all cancers and is the fourth highest cancer killer worldwide. Novel, more effective strategies are needed to treat this disease. We report here on the use of patient-like orthotopic nude-mouse models of human metastatic pancreatic cancer to compare the traditional Chinese medicine (TCM) herbal mixture LQ to gemcitabine, which is first-line therapy for this disease, for anti-metastatic and anti-tumor activity as well as safety. The human pancreatic cancer cell line, MiaPaCa-2, labeled with red fluorescent protein (RFP), was used for the orthotopic model. LQ (gavage, 600 mg/kg/day) significantly inhibited pancreatic cancer tumor growth and metastasis, as measured by imaging, with no overt toxicity. Survival of tumor-bearing mice was also prolonged by LQ. The therapeutic efficacy of LQ is comparable with gemcitabine but with less toxicity, as indicated by a lack of body-weight loss with LQ, but not gemcitabine. The results indicate that TCM can have non-toxic efficacy against metastatic pancreatic cancer comparable to gemcitabine in a clinically-relevant orthotopic mouse model.
胰腺癌的治疗极具挑战性，其死亡率在所有癌症中位居前列，是全球第四大致癌杀手。因此，需要寻找新的、更有效的策略来治疗这种疾病。我们在此报告了使用类似于患者的原位裸鼠人转移性胰腺癌模型来比较传统中药（TCM）草药混合物 LQ 与吉西他滨（用于治疗该疾病的一线药物）在抗转移和抗肿瘤活性以及安全性方面的效果。我们使用红色荧光蛋白（RFP）标记的人胰腺癌细胞系 MiaPaCa-2 建立了原位模型。通过成像测量，LQ（灌胃，每天 600mg/kg）显著抑制了胰腺癌肿瘤的生长和转移，没有明显的毒性。LQ 还延长了荷瘤小鼠的生存时间。LQ 的治疗效果可与吉西他滨相媲美，但毒性更小，LQ 不会导致体重减轻，而吉西他滨则会。这些结果表明，在临床相关的原位小鼠模型中，TCM 可以对转移性胰腺癌产生无毒且与吉西他滨相当的疗效。
