Liu Lihua, Zhang Ming, Wang Yuan, Li Min
Center of Image, the First Affilliated Hospital to Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi Province 710061,China.
J Biomed Res. 2010 Mar;24(2):124-31. doi: 10.1016/S1674-8301(10)60020-6.
To investigate the relationship between the expression level of matrix-metalloproteinases (MMPs) with the pathological grades and MRI characteristics of human gliomas.
Prior pre- and post-contrast enhancement MRI was performed on 31 patients with gliomas, which were confirmed by post-operational pathology. The expression of MMP-2 and MMP-9 were determined by immunohistochemical staining in both a low grading group (grades I and II, n = 20) and high grading group (grades III and IV, n = 11).
Compared to the low grading group, the expression levels of MMP-2, MMP-9, as well as the tumor edema index (EI), enhanced percentage (EP) and maximum diameters were significantly greater in the high grading group. MMP-2 and MMP-9 expression were correlated with the tumor EI, EP and the maximum diameters. There were no differences in MMP-2 and MMP-9 expression between the unclear border definition group and the clear border definition group, whereas the MMPs expression levels were greater in the heterogeneous signal group than in the homogeneous signal group.
The expression level of MMPs is correlated with the invasion ability of human gliomas. The MRI parameters, such as tumor EI, EP, maximum diameter, and signal heterogeneity technically reflect the expression level of MMPs, and can be used to estimate the tumor's malignant behavior, thus providing the guidance for clinical therapies.
探讨基质金属蛋白酶（MMPs）表达水平与人类胶质瘤病理分级及MRI特征之间的关系。
对31例经术后病理证实的胶质瘤患者术前行增强MRI检查。采用免疫组织化学染色法检测低级别组（Ⅰ级和Ⅱ级，n = 20）和高级别组（Ⅲ级和Ⅳ级，n = 11）中MMP - 2和MMP - 9的表达。
与低级别组相比，高级别组中MMP - 2、MMP - 9的表达水平以及肿瘤水肿指数（EI）、强化百分比（EP）和最大直径均显著更高。MMP - 2和MMP - 9的表达与肿瘤EI、EP及最大直径相关。边界不清组与边界清晰组之间MMP - 2和MMP - 9的表达无差异，而异质信号组中MMPs的表达水平高于均匀信号组。
MMPs的表达水平与人类胶质瘤的侵袭能力相关。MRI参数，如肿瘤EI、EP、最大直径和信号异质性在技术上反映了MMPs的表达水平，可用于评估肿瘤的恶性行为，从而为临床治疗提供指导。
