Sasabe T, Takahashi T, Hagiwara A, Iwamoto A, Shimotsuma M, Yoneyama C, Itoh M, Hyon S H, Ikeda Y, Kusanoi Y
1st Dept. of Surgery, Kyoto Prefectural Univ.
Gan No Rinsho. 1990 Jun;36(7):821-3.
We have evaluated the acute toxicity of an experimental new dosage form administered intraperitoneally in mice, consisting of cis-platinum loaded with lactic acid oligomer microspheres (CDDP-ms). The LD50 value of the CDDP-ms was 23.8 mg/kg, which amounted to 176% of the LD50 of the cis-platinum solution (13.5 mg/kg). Autopsy findings revealed no additional toxicity due to this dosage form.
我们评估了一种实验性新剂型经腹腔注射给予小鼠后的急性毒性，该剂型为由载有乳酸低聚物微球的顺铂（CDDP-ms）组成。CDDP-ms的半数致死量（LD50）值为23.8mg/kg，相当于顺铂溶液LD50（13.5mg/kg）的176%。尸检结果显示该剂型无额外毒性。
