Zhang Min, Zhang Yan, Zhu Shuaishuai, Li Xiaoyu, Yang Qing, Bai Hui, Chen Qi
Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Institute of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China;
J Biomed Res. 2012 Nov;26(6):418-24. doi: 10.7555/JBR.26.20110116. Epub 2012 Sep 28.
The class A scavenger receptor, encoded by the macrophage scavenger receptor 1 (MSR1) gene, is a pattern recognition receptor (PPR) primarily expressed in macrophages. It has been reported that genetic polymorphisms of MSR1 are significantly associated with the number of diseased vessels and coronary artery narrowing greater than 20% in Caucasians. However, whether it links genetically to coronary artery disease (CAD) in Chinese is not defined. Here, we performed an independent case-control study in a Chinese population consisting of 402 CAD cases and 400 controls by genotyping ten single nucleotide polymorphisms (SNPs) of MSR1. We found that rs416748 and rs13306541 were significantly associated with an increased risk of CAD with per allele odds ratio (OR) of 1.56 [95% confidence interval (CI) = 1.28-1.90; P < 0.001] and 1.70 (95% CI = 1.27-2.27; P < 0.001), respectively. Our results indicate that genetic variants of MSR1 may serve as predictive markers for the risk of CAD in combination with traditional risk factors of CAD in Chinese population.
A类清道夫受体由巨噬细胞清道夫受体1（MSR1）基因编码，是一种主要在巨噬细胞中表达的模式识别受体（PPR）。据报道，MSR1的基因多态性与白种人中病变血管数量及冠状动脉狭窄超过20%显著相关。然而，在中国人群中它是否与冠状动脉疾病（CAD）存在遗传关联尚不清楚。在此，我们通过对MSR1的十个单核苷酸多态性（SNP）进行基因分型，在中国人群中开展了一项独立的病例对照研究，该人群包括402例CAD病例和400例对照。我们发现，rs416748和rs13306541与CAD风险增加显著相关，每个等位基因的比值比（OR）分别为1.56 [95%置信区间（CI）= 1.28 - 1.90；P < 0.001]和1.70（95% CI = 1.27 - 2.27；P < 0.001）。我们的结果表明，在中国人群中，MSR1的基因变异可能与CAD传统风险因素相结合，作为CAD风险的预测标志物。
