SERCO, Département de Chimie Moléculaire, University Grenoble Alpes, ICMG FR-2607, CNRS, UMR-5250, F-38041 Grenoble, France.
J Org Chem. 2013 May 17;78(10):4840-9. doi: 10.1021/jo400386f. Epub 2013 Apr 29.
Naturally occurring hyacinthacines B1 and B2 have been prepared from a common, easily available, advanced intermediate. The approach features several highly stereoselective transformations: inter alia, a dichloroketene-enol ether [2 + 2] cycloaddition, a Bruylants alkylation, and an amino-nitrile alkylation-reduction.
天然的百部定碱 B1 和 B2 可以从一个常见的、容易获得的、高级的中间体中制备得到。该方法具有多个高度立体选择性的转化：例如，二氯亚甲基-烯醇醚 [2 + 2] 环加成、Bruylants 烷基化以及氨基腈烷基化-还原。
