Zhou Changyan, Qiao Yanru, Tang Qingjiu, Jia Wei, Liu Yanfang, Wu Aizhong
Shanghai Jiao Tong University, School of Agriculture and Biology, Shanghai, China.
Int J Med Mushrooms. 2013;15(2):145-52. doi: 10.1615/intjmedmushr.v15.i2.30.
A novel small-molecule polysaccharide with a molecular mass of 2.6 kDa, was isolated from the culinary-medicinal Maitake mushroom Grifola frondosa. GFPS is composed of fucose, rhamnose, galactose, glucose, and mannose; galactose, glucose, and mannose were the dominant monosaccharides. Absorption peaks at 1077 cm-1, 1024 cm-1, and 873 cm-1, as revealed by infrared spectrum, suggesting that GFPS consists of pyranoside. GFPS significantly enhanced the production of nitric oxide and secretion of cytokines (tumor necrosis factor-α, interleukin-1β, and interleukin-δ) from macrophages in vitro. These results indicate that this novel small-molecule polysaccharide might be beneficial for immune defense.
从药食兼用的灰树花（Grifola frondosa）中分离出一种分子量为2.6 kDa的新型小分子多糖。GFPS由岩藻糖、鼠李糖、半乳糖、葡萄糖和甘露糖组成；半乳糖、葡萄糖和甘露糖是主要的单糖。红外光谱显示在1077 cm-1、1024 cm-1和873 cm-1处有吸收峰，表明GFPS由吡喃糖苷组成。GFPS在体外显著增强了巨噬细胞中一氧化氮的产生和细胞因子（肿瘤坏死因子-α、白细胞介素-1β和白细胞介素-δ）的分泌。这些结果表明，这种新型小分子多糖可能对免疫防御有益。
