Matsumoto Ayako, Yajima Hiroyuki, Murata Tomoya, Gotou Kousuke, Okamoto Kenta, Nishiyama Hitoshi
Department of Gastroenterology, National Hospital Organization Nagasaki Medical Center.
Nihon Shokakibyo Gakkai Zasshi. 2013 Apr;110(4):639-47.
A 30-year-old woman was referred to our hospital with recurrent refractory ulcerative colitis. She also suffered from avascular necrosis of the left femoral head caused by steroid use. We had expected that tacrolimus would contribute to remission, but effects remained insufficient even after 16 days of treatment. Intensive leukocytapheresis (LCAP) therapy was added to tacrolimus therapy, and this combination achieved remission. Tacrolimus plus intensive LCAP combination therapy appears useful in treating refractory ulcerative colitis.
一名30岁女性因复发性难治性溃疡性结肠炎转诊至我院。她还因使用类固醇导致左侧股骨头缺血性坏死。我们曾期望他克莫司能有助于病情缓解，但治疗16天后效果仍不充分。在他克莫司治疗基础上加用强化白细胞去除术（LCAP）治疗，这种联合治疗实现了病情缓解。他克莫司加强化LCAP联合治疗似乎对治疗难治性溃疡性结肠炎有效。
