Department of Pathology and Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan.
Mod Pathol. 2013 Aug;26(8):1041-50. doi: 10.1038/modpathol.2013.54. Epub 2013 Apr 5.
Salivary gland tumors are relatively rare and morphologically diverse and heterogeneous tumors; therefore, histogenesis-based tumor markers are sorely needed to aid in diagnosing and determining the cell type of origin. SRY-related HMG-box 10 (SOX10) protein is a transcription factor known to be crucial in the specification of the neural crest and maintenance of Schwann cells and melanocytes. In addition, positive expression has also been implicated in the major salivary gland. Here, we examined SOX10 expression in various salivary gland tumors to correlate this expression with myoepithelial markers. Overall, 76 malignant and 14 benign tumors were examined. SOX10 expression clearly delineated two distinct subtypes of human salivary gland tumors; acinic cell carcinomas, adenoid cystic carcinomas, epithelial-myoepithelial carcinomas, myoepithelial carcinomas, and pleomorphic adenomas, including the pleomorphic adenoma component of carcinoma, were SOX10 positive, while salivary duct carcinomas, mucoepidermoid carcinomas, an oncocytic carcinoma, Oncocytomas, and Warthin tumors were SOX10 negative. Also, SOX10 was expressed in solid-type or non-specific morphology salivary gland tumors, but was not expressed in poorly differentiated squamous cell carcinomas. In normal human salivary gland tissue, SOX10 expression was specific to the nuclei of acini and both luminal and abluminal cells of intercalated ducts but not in other sites. Moreover, the murine model suggested that SOX10 continued to be expressed from the developmental stage to adulthood in the acinar and both luminal and abluminal intercalated ducts in the major salivary gland. Thus, SOX10 is a novel marker for diagnosing and understanding the histogenesis of salivary gland tumors.
唾液腺肿瘤是相对罕见的，具有形态多样和异质性的肿瘤；因此，基于组织发生的肿瘤标志物非常需要帮助诊断和确定细胞起源类型。与 SRY 相关的高迁移率族盒 10（SOX10）蛋白是一种已知在神经嵴的特化和施万细胞和黑色素细胞的维持中起关键作用的转录因子。此外，阳性表达也与主要唾液腺有关。在这里，我们检查了各种唾液腺肿瘤中的 SOX10 表达，以将这种表达与肌上皮标志物相关联。总体而言，检查了 76 例恶性肿瘤和 14 例良性肿瘤。SOX10 表达清楚地区分了两种不同类型的人类唾液腺肿瘤；腺泡细胞癌、腺样囊性癌、上皮-肌上皮癌、肌上皮癌和多形性腺瘤，包括癌的多形性腺瘤成分，SOX10 阳性，而唾液导管癌、黏液表皮样癌、嗜酸细胞癌、嗜酸细胞瘤和沃辛瘤则 SOX10 阴性。此外，SOX10 在实体型或非特异性形态唾液腺肿瘤中表达，但在低分化鳞状细胞癌中不表达。在正常的人类唾液腺组织中，SOX10 表达特异性地位于腺泡的细胞核以及中间导管的腔侧和基底侧细胞，但不在其他部位表达。此外，鼠模型表明，SOX10 在主要唾液腺的腺泡以及腔侧和基底侧中间导管中从发育阶段持续表达到成年期。因此，SOX10 是诊断和理解唾液腺肿瘤发生的新型标志物。
