Division of LifeSciences, Korea Polar Research Institute, KOPRI, Songdo Technopark, Songdo-dong 7-50, Yeonsu-gu, Incheon 406-840, South Korea.
Biol Res. 2012;45(4):387-91. doi: 10.4067/S0716-97602012000400010.
A total of twenty four lichen species belonging to six families were collected from mountainous region of Nepal. The methanol extracts of each species were tested for antimicrobial and antioxidant activities in vitro. It was found that extracts of twenty one lichen species were active against B. subtilis and seven species were active against S. aureus. Similarly, in DPPH assay, three species Peltigera sp.,Cladonia sp., and Canoparmelia sp. showed comparable activity with commercial standard, BHA. In ABTS+ assay, extracts of Parmoterma sp., Ramalina sp., Peltigera sp. and Cladonia sp. showed stronger activity than ascorbic acid. The observed data after comparison with previously published reports indicated that the high altitude lichens contain stronger antioxidant and antibacterial constituents. Similarly, the methanol extracts of Heterodermia sp. and Ramalina sp. showed comparable toxicity effect with commercial standard berberine chloride indicating a potent source of anticancer drugs.
共从尼泊尔山区采集到 24 种属于 6 科的地衣物种。对每种物种的甲醇提取物进行了体外抗菌和抗氧化活性测试。结果发现，21 种地衣物种的提取物对枯草芽孢杆菌有活性，7 种地衣物种对金黄色葡萄球菌有活性。同样，在 DPPH 测定中，3 种地衣物种（Peltigera sp.、Cladonia sp. 和 Canoparmelia sp.）与商业标准 BHA 具有相当的活性。在 ABTS+测定中，Parmoterma sp.、Ramalina sp.、Peltigera sp. 和 Cladonia sp. 的提取物比抗坏血酸具有更强的活性。与之前发表的报告进行比较后观察到的数据表明，高海拔地衣含有更强的抗氧化和抗菌成分。同样，Heterodermia sp. 和 Ramalina sp. 的甲醇提取物对商业标准盐酸小檗碱表现出相当的毒性作用，表明它们是潜在的抗癌药物来源。
