[小鼠出生前和出生后个体发育中的克隆造血细胞（CFU-S）]

[Clonogenic hemopoietic cells (CFU-S) in mouse pre- and postnatal ontogeny].

作者信息

Domaratskaia E I, Prianishnikova O D, Khrushchov N G

出版信息

Ontogenez. 1990 Jan-Feb;21(1):81-8.

Abstract

Content of three classes of clonogenic haemopoietic cells (CFU-S-7, CFU-S-11 and CFU-S-ep) was determined in haemopoietic organs of mouse during embryogenesis (10, 14 and 18 day) and postnatal ontogenesis (2, 3 and 7 day, 1, 2, 3 and 18 month). CFU-S-7 and CFU-S-11 that from big splenic colonies on 7th and 11th days of transplantation are present in liver, spleen and bone marrow at all developmental stages. However their concentration and CFU-S-7 CFU-S-11 ratio change in haemopoietic organs. CFU-S-ep that form small colonies on 11th day are observed before birth in liver and spleen and 1 week after birth there and also in bone marrow but are practically absent from haemopoietic organs of older animals. Thus, CFU-S compartment structure is characterized by definite ratio of its subpopulations. It seems to reflect functional state of haemopoietic system during development.

摘要

在小鼠胚胎发育阶段（第10、14和18天）以及出生后个体发育阶段（第2、3和7天，1、2、3和18个月），对其造血器官中三类克隆性造血细胞（CFU-S-7、CFU-S-11和CFU-S-ep）的含量进行了测定。在移植后第7天和第11天形成大脾脏集落的CFU-S-7和CFU-S-11，在所有发育阶段的肝脏、脾脏和骨髓中均有存在。然而，它们在造血器官中的浓度以及CFU-S-7与CFU-S-11的比例会发生变化。在出生前，在肝脏和脾脏中可观察到在第11天形成小集落的CFU-S-ep，出生后1周在肝脏、脾脏以及骨髓中也能观察到，但在成年动物的造血器官中实际上并不存在。因此，CFU-S区室结构的特征在于其子群体的特定比例。这似乎反映了发育过程中造血系统的功能状态。