Kawashima Y, Saito M, Takenaka H
J Pharm Pharmacol. 1975 Jan;27(1):1-5. doi: 10.1111/j.2042-7158.1975.tb09369.x.
Spray drying techniques have been applied to improve the solubility and dissolution rate of poorly water-soluble salicylic acid. Spray drying of the acid dispersed in acacia solutions resulted in as much as a 50% improvement in the solubility of the product. Solubility improvement was closely related not only to the concentration of acacia but also the amount of amorphous material in the spray-dried products. The heat of solution was inversely related to these parameters. The dissolution rate of spray-dried product was almost instantaneous being about 60 times faster than that of the original powder. A great improvement in the wettability of the spray-dried material seemed to be mainly responsible for the increase of dissolution rate.
喷雾干燥技术已被应用于提高难溶性水杨酸的溶解度和溶解速率。将酸分散在阿拉伯胶溶液中进行喷雾干燥，可使产品的溶解度提高多达50%。溶解度的提高不仅与阿拉伯胶的浓度密切相关，还与喷雾干燥产品中的无定形物质含量有关。溶解热与这些参数呈负相关。喷雾干燥产品的溶解速率几乎是瞬间的，比原粉末快约60倍。喷雾干燥材料润湿性的大幅提高似乎是溶解速率增加的主要原因。
