[Concentration of selected sex hormones and SHBG in the serum of women with breast cancer treated with antiestrogens and (or) cytostatic agents].

The concentration of sex hormones prolactin, LH, FSH, estradiol, testosterone and SHGB has been estimated in 34 premenopausal women with breast cancer, including 10 treated by radiologic castration, 22 treated with cytostatics, 26 treated with tamoxifen and 14 treated with tamoxifen and cytostatics. Concentration of sex hormones has been estimated applying radioimmunological methods, and of SHBG with filtration method using DEAE cellulose filters. It has been found that chemotherapy of breast cancer of premenopausal women results in decrease of concentration of estradiol, testosterone, prolactin and SHGB down to the values approaching postcastration values and the application of cytostatics and of tamoxifen in postmenopausal women is not resulting in the decrease of concentration of these hormones and SHGB to the degree justifying a routine application of these drugs simultaneously.