Department of Cardiothoracic Surgery, Mount Sinai Medical Center, New York, NY 10029, USA.
Ann Thorac Surg. 2013 May;95(5):1563-9. doi: 10.1016/j.athoracsur.2013.02.039. Epub 2013 Apr 3.
Despite clinical and technical advances, acute aortic dissection carries high operative mortality. This study was designed to establish whether this is influenced by institution and surgeon volume.
Outcomes of 5,184 patients (mean age, 60.3 years; 65.9% male) diagnosed with acute aortic dissection from the Nationwide Inpatient Sample from 2003 to 2008 were analyzed with risk-adjustment for preoperative comorbidity using multivariate logistic regression analysis.
Overall operative mortality was 21.6%, with similar preoperative patient risk profile across institutions and individual surgeons. A strong inverse relationship was observed between operative mortality and both institution and surgeon volume: surgeons who averaged less than 1 aortic dissection repair annually had a mean operative mortality of 27.5%, compared with 17.0% for those averaging 5 or more annually (odds ratio, 1.78; 95% confidence interval, 1.39 to 2.29; p < 0.001). This was similar to the relationship seen between institution volume and mortality: operative mortality was 27.4% in institutions performing 3 or fewer acute aortic dissections a year, compared with 16.4% in those performing more than 13 annually (p < 0.001). Nationally, operative mortality decreased steadily from 23% in 1998-2000 to 19% in 2005-2008, with no significant decrease in patient risk profile.
Patients undergoing emergency repair of acute aortic dissection by lower-volume surgeons and centers have approximately double the risk-adjusted mortality of patients undergoing repair by the highest volume care providers. Routine involvement, whenever feasible, of teams experienced in acute aortic dissection repair may be a strategy to reduce operative mortality and major morbidity.
尽管临床和技术有所进步,急性主动脉夹层的手术死亡率仍然很高。本研究旨在确定这是否受到机构和外科医生数量的影响。
分析了 2003 年至 2008 年期间全国住院患者样本中 5184 名(平均年龄 60.3 岁;65.9%为男性)急性主动脉夹层患者的结果,使用多变量逻辑回归分析对术前合并症进行风险调整。
总体手术死亡率为 21.6%,各机构和外科医生的术前患者风险状况相似。手术死亡率与机构和外科医生数量呈明显负相关:每年平均少于 1 例主动脉夹层修复的外科医生的手术死亡率为 27.5%,而每年平均 5 例或更多的外科医生的手术死亡率为 17.0%(比值比,1.78;95%置信区间,1.39 至 2.29;p<0.001)。这与机构数量与死亡率之间的关系相似:每年进行 3 次或更少急性主动脉夹层手术的机构的手术死亡率为 27.4%,而每年进行 13 次或更多手术的机构的手术死亡率为 16.4%(p<0.001)。全国范围内,手术死亡率从 1998-2000 年的 23%稳步下降到 2005-2008 年的 19%,而患者的风险状况没有明显下降。
由低容量外科医生和中心进行的急性主动脉夹层紧急修复的患者,其风险调整死亡率是由最高容量护理提供者进行修复的患者的两倍左右。只要可行,让经验丰富的急性主动脉夹层修复团队参与常规治疗可能是降低手术死亡率和主要发病率的一种策略。