Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15 West 7, Kita-ku, Sapporo, Hokkaido, Japan.
Neurosci Lett. 2013 May 24;543:42-6. doi: 10.1016/j.neulet.2013.02.059. Epub 2013 Apr 2.
To evaluate neurocognitive functions of patients with social anxiety disorder (SAD) without comorbidity using neuropsychological assessments and to investigate the relation between neurocognitive functions and clinical severity of SAD, this study assessed 30 SAD patients (10 female, 20 male) without comorbidity and 30 healthy subjects matched on gender, education level, and age. The neuropsychological assessment consisted of the Wisconsin card sorting test (WCST), the continuous performance test, the trail-making test, the word fluency test, and the auditory verbal learning test. On the WCST, patients showed lower performance than healthy controls did. The Liebowitz Social Anxiety Scale score correlated significantly with the numbers of perseverative errors of the WCST, although the State anxiety score of State-Trait Anxiety Inventory and the Beck Depression Inventory - Second Edition score showed no correlation with neuropsychological test scores. Results show that the executive functioning of patients with SAD was low and that the low functioning correlates with the SAD symptom severity.
为了使用神经心理学评估来评估无共病的社交焦虑障碍(SAD)患者的神经认知功能,并研究神经认知功能与 SAD 临床严重程度之间的关系,本研究评估了 30 名无共病的 SAD 患者(10 名女性,20 名男性)和 30 名在性别、教育程度和年龄上相匹配的健康受试者。神经心理学评估包括威斯康星卡片分类测试(WCST)、连续性能测试、连线测试、词汇流畅性测试和听觉词语学习测试。在 WCST 上,患者的表现低于健康对照组。利博维茨社交焦虑量表(Liebowitz Social Anxiety Scale)评分与 WCST 的持续错误数量显著相关,尽管状态特质焦虑量表(State-Trait Anxiety Inventory)的状态焦虑评分和贝克抑郁量表第二版(Beck Depression Inventory - Second Edition)评分与神经心理学测试评分无关。结果表明,SAD 患者的执行功能较低,低功能与 SAD 症状严重程度相关。