辐射诱导的DNA双链断裂修复的动力学分析
A kinetic analysis of the repair of radiation-induced DNA double-strand breaks.
作者信息
Tseng S, Hsu J P
机构信息
Department of Mathematics, Tamkang University, Taiwan, Republic of China.
出版信息
Radiat Res. 1990 Jun;122(3):333-6.
PMID:2356288
Abstract
The repair of radiation-induced DNA double-strand breaks (DSBs) is analyzed kinetically. It is assumed that a fraction of the damaged sites in the DNA duplex are irreparable. The kinetic model takes the effect of radiation dose into account. The analysis of the available experimental data reveals that, although the number of irreparable DSBs is a quadratic function of radiation dose, the normalized number of irreparable DSBs correlates linearly with this variable.
摘要
对辐射诱导的DNA双链断裂（DSB）的修复进行了动力学分析。假设DNA双链中一部分受损位点是无法修复的。动力学模型考虑了辐射剂量的影响。对现有实验数据的分析表明，尽管无法修复的DSB数量是辐射剂量的二次函数，但无法修复的DSB的归一化数量与该变量呈线性相关。
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