Taylor G J, Drew R T
J Pharmacol Exp Ther. 1975 Jan;192(1):129-35.
The effects of inhaling fluorocarbon 12, a common propellant in household aerosols, were studied in closed-chested rabbits. Inhalation of 10 or 20% fluorocarbon 12 produced a decline in cardiac output and a dose-related depression of peak left ventricular (LV) dP/dt without associated arrthythmias, hypoxemia or significant changes in LV end-diastolicpressue or heart rate. There was a small decline in LV systolic pressure without a significant drop in mean arterial pressure. Breathing fluorocarbon 12 for 30 minutes caused a decline in peak LV dP/dt, cardiac output, LV systolic pressure and mean arterial pressure which was present throughout the exposure period. The effects observed during acute fluorocarbon 12 exposure were not altered by previous chronic, intermittent exposure to 10% fluorocarbon 12.
在家用气雾剂中常用的推进剂氟利昂-12对家兔闭胸模型的影响进行了研究。吸入10%或20%的氟利昂-12会导致心输出量下降以及左心室（LV）dp/dt峰值出现剂量相关的降低，且未伴有心律失常、低氧血症或左心室舒张末期压力或心率的显著变化。左心室收缩压略有下降，但平均动脉压无显著下降。吸入氟利昂-12 30分钟会导致左心室dp/dt峰值、心输出量、左心室收缩压和平均动脉压下降，且在整个暴露期均存在。先前长期、间歇性暴露于10%氟利昂-12并不会改变急性暴露于氟利昂-12期间观察到的效应。
