Witten/Herdecke University, School of Medicine, Department of Electrophysiology, St. Agnes-Hospital Bocholt, Barloer Weg 125, GER-46397 Bocholt, Germany.
Europace. 2013 Nov;15(11):1642-50. doi: 10.1093/europace/eut056. Epub 2013 Apr 5.
There are only few descriptions of patients without prior cardiac surgery in whom a large low-voltage zone (LVZ) or scar is the electrophysiological substrate for various atrial tachycardias. We describe the electrophysiological and electroanatomic characteristics of unusual macroreentrant atrial tachycardias (MRATs) in seven patients with spontaneous right atrial (RA) scarring and present long-term follow-up results.
In 7 of 326 patients with MRAT treated with radiofrequency ablation we detected regions of RA spontaneous LVZ or scarring during conventional mapping of the arrhythmia. They underwent electroanatomic mapping and catheter ablation of the spontaneous and further induced arrhythmias with a long-term follow-up. A total of 17 different atrial tachycardias were observed with typical atrial flutter in four patients. In five patients a LVZ was found in the RA free wall and two patients had a septal scar. Stable circuits were around the scar or LVZ in four patients and through a 'channel' within the scar in two. Radiofrequency ablation sites included the cavotricuspid isthmus for typical atrial flutter, between the inferior vena cava and scar, a channel in the scar or the left atrial (LA) mitral isthmus. During follow-up of 34 ± 5 months, four patients were free from atrial tachycardias. Both patients with a septal RA scar developed LA tachycardias, requiring further catheter ablation. One patient presented with a novel type of atypical scar-related RA flutter.
Mapping and ablation of scar-related RA tachycardias is an effective treatment but does not preclude the development of further tachycardias, some of them arising from the LA during long-term follow-up.
仅有少数描述表明,在无先前心脏手术史的患者中,大面积低电压区(LVZ)或瘢痕是各种房性心动过速的电生理基质。我们描述了 7 例具有自发性右心房(RA)瘢痕的患者中不同的大折返性房性心动过速(MRAT)的电生理和电解剖特征,并呈现了长期随访结果。
在 326 例接受射频消融治疗的 MRAT 患者中,我们在心律失常的常规标测中发现了 7 例 RA 自发性 LVZ 或瘢痕区域。对这些患者进行电解剖标测和导管消融自发性和进一步诱发性心律失常,并进行长期随访。共观察到 17 种不同的房性心动过速,其中 4 例为典型的心房扑动。5 例患者的 RA 游离壁存在 LVZ,2 例患者存在间隔瘢痕。在 4 例患者中,稳定的环围绕着瘢痕或 LVZ,在 2 例患者中,稳定的环通过瘢痕内的“通道”形成。射频消融部位包括三尖瓣峡部以治疗典型的心房扑动、下腔静脉与瘢痕之间、瘢痕内的“通道”或左心房(LA)二尖瓣峡部。在 34±5 个月的随访期间,4 例患者无房性心动过速。2 例间隔 RA 瘢痕患者发生 LA 心动过速,需要进一步导管消融。1 例患者出现了一种新的非典型瘢痕相关的 RA 扑动。
针对瘢痕相关 RA 心动过速的标测和消融是一种有效的治疗方法,但并不能排除在长期随访中发生进一步心动过速的可能,其中一些可能起源于 LA。